Basic Information
ID: ALA4619471
Type: Binding
Description: Protac activity at cereblon/PDE6D in EGF-stimulated human SW480 cells assessed as inhibition of RAS signaling by measuring reduction in ERK phosphorylation at 5 to 20 uM incubated for 12 hrs dosed after 5 mins pre-incubation with EGF by Western blotting analysis
Format: BAO_0000218
Organism: Homo sapiens
Cell type: SW480
Target: Protein cereblon/Phosphodiesterase 6D(ALA4630727)
Document: ALA4616722
Protac activity at cereblon/PDE6D in EGF-stimulated human SW480 cells assessed as inhibition of RAS signaling by measuring reduction in ERK phosphorylation at 5 to 20 uM incubated for 12 hrs dosed after 5 mins pre-incubation with EGF by Western blotting analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4619471
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 457.58 | 4.21 | 4.21 |
| 722.85 | 4.26 | 4.26 |