Basic Information
ID: ALA4620710
Type: Binding
Description: Inverse agonist activity at RORgammat in human whole blood assessed as inhibition of anti-CD3/anti-CD28 monoclonal antibodies-stimulated IL-17A production at 1 uM measured after 3 days by ELISA relative to JNJ-54271074
Format: BAO_0000221
Organism: Homo sapiens
Tissue: Blood
Target: Nuclear receptor ROR-gamma(ALA1741186)
Document: ALA4619752
Inverse agonist activity at RORgammat in human whole blood assessed as inhibition of anti-CD3/anti-CD28 monoclonal antibodies-stimulated IL-17A production at 1 uM measured after 3 days by ELISA relative to JNJ-54271074: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4620710
Efficacy
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 557.78 | 5.66 | 5.66 |
| 643.54 | 4.61 | 4.61 |
| 663.54 | 4.81 | 4.81 |
| 645.55 | 4.86 | 4.86 |
| 701.59 | 5.61 | 5.61 |
| 679.52 | 4.86 | 4.86 |
| 649.10 | 5.00 | 5.00 |
| 635.53 | 5.49 | 5.49 |
| 645.55 | 4.72 | 4.72 |
| 651.53 | 4.67 | 4.67 |
| 572.75 | 4.17 | 4.17 |
| 645.55 | 4.52 | 4.52 |
| 657.56 | 4.86 | 4.86 |
| 704.60 | 4.37 | 4.37 |
| 687.51 | 5.26 | 5.26 |
| 633.54 | 4.72 | 4.72 |
| 673.49 | 4.87 | 4.87 |
| 643.13 | 4.47 | 4.47 |
| 632.65 | 4.49 | 4.49 |
| 663.54 | 4.81 | 4.81 |
| 619.51 | 4.33 | 4.33 |
| 658.53 | 5.20 | 5.20 |
| 721.60 | 4.18 | 4.18 |
| 649.52 | 4.42 | 4.42 |
| 663.54 | 4.81 | 4.81 |
| 667.51 | 4.72 | 4.72 |
| 655.50 | 4.57 | 4.57 |
| 631.53 | 4.47 | 4.47 |
| 677.57 | 5.20 | 5.20 |
| 680.64 | 4.88 | 4.88 |
| 631.53 | 4.47 | 4.47 |
| 663.54 | 4.81 | 4.81 |
| 631.53 | 4.47 | 4.47 |
| 667.51 | 4.72 | 4.72 |
| 658.69 | 5.02 | 5.02 |
| 629.51 | 3.94 | 3.94 |
| 666.61 | 4.49 | 4.49 |
| 633.54 | 4.72 | 4.72 |
| 633.54 | 4.72 | 4.72 |
| 653.48 | 4.33 | 4.33 |
| 684.60 | 4.57 | 4.57 |
| 649.52 | 5.02 | 5.02 |
| 649.52 | 4.42 | 4.42 |
| 723.62 | 4.62 | 4.62 |
| 644.66 | 4.63 | 4.63 |
| 645.55 | 4.86 | 4.86 |
| 690.57 | 4.55 | 4.55 |
| 657.56 | 4.86 | 4.86 |