Basic Information
ID: ALA4621293
Type: ADME
Description: Inhibition of recombinant human CYP3A4 expressed in baculovirus infected insect cell microsomes using vivid DBOMF as substrate preincubated for 10 mins followed by substrate addition and measured after 25 mins in presence of NAD+ by fluorescence assay
Organism: Homo sapiens
Subcellular Fraction: Microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA4621293
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 390.57 | 6.02 | 6.02 |
| 428.91 | 6.19 | 6.19 |
| 394.53 | 6.11 | 6.11 |
| 390.57 | 5.73 | 5.73 |
| 406.61 | 6.52 | 6.52 |
| 428.62 | 6.39 | 6.39 |
| 388.43 | 4.89 | 4.89 |
| 390.57 | 6.53 | 6.53 |
| 352.43 | 3.71 | 3.71 |