Basic Information
ID: ALA4622179
Type: Binding
Description: Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abeta42 production after 24 hrs by Alphalisa assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4622179
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 438.48 | 3.76 | 3.76 |
| 452.51 | 4.15 | 4.15 |
| 427.53 | 2.24 | 2.24 |
| 453.49 | 3.55 | 3.55 |
| 423.40 | 2.69 | 2.69 |
| 505.42 | 4.10 | 4.10 |
| 486.42 | 4.41 | 4.41 |
| 467.52 | 3.94 | 3.94 |
| 439.47 | 3.16 | 3.16 |
| 371.47 | 2.22 | 2.22 |
| 473.41 | 3.32 | 3.32 |
| 481.45 | 4.30 | 4.30 |
| 425.44 | 3.11 | 3.11 |
| 483.45 | 3.82 | 3.82 |
| 472.42 | 3.93 | 3.93 |
| 505.42 | 4.10 | 4.10 |
| 506.48 | 4.78 | 4.78 |
| 453.49 | 3.55 | 3.55 |
| 437.43 | 3.08 | 3.08 |
| 491.40 | 3.71 | 3.71 |
| 471.51 | 4.30 | 4.30 |