Basic Information
ID: ALA4622741
Type: Binding
Description: Antagonist activity at human TLR7 overexpressed in HEK-Blue cells assessed as inhibition of gardiquimod-induced NFkappaB and AP-1 activation preincubated for 30 mins followed by gardiquimod stimulation measured after 22 hrs by quanti-blue SEAP assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4622741
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 381.50 | 4.38 | 4.38 |
| 350.46 | 4.63 | 4.63 |
| 449.64 | 5.73 | 5.73 |
| 390.53 | 3.64 | 3.64 |
| 418.54 | 4.12 | 4.12 |
| 385.91 | 5.03 | 5.03 |
| 449.64 | 5.76 | 5.76 |
| 435.61 | 5.37 | 5.37 |
| 377.53 | 4.55 | 4.55 |
| 475.56 | 5.36 | 5.36 |
| 421.59 | 4.81 | 4.81 |
| 441.58 | 5.94 | 5.94 |
| 361.53 | 4.85 | 4.85 |
| 447.62 | 5.43 | 5.43 |
| 427.98 | 4.90 | 4.90 |
| 421.59 | 4.95 | 4.95 |
| 361.53 | 4.85 | 4.85 |
| 405.54 | 4.31 | 4.31 |
| 391.52 | 4.27 | 4.27 |
| 361.53 | 4.85 | 4.85 |
| 392.50 | 4.89 | 4.89 |
| 372.52 | 4.41 | 4.41 |
| 461.65 | 5.82 | 5.82 |
| 444.58 | 5.27 | 5.27 |
| 377.53 | 4.55 | 4.55 |
| 372.52 | 4.41 | 4.41 |
| 444.58 | 5.27 | 5.27 |
| 407.56 | 4.56 | 4.56 |
| 407.56 | 4.56 | 4.56 |
| 421.59 | 4.57 | 4.57 |
| 372.52 | 4.41 | 4.41 |
| 377.53 | 4.55 | 4.55 |
| 444.58 | 5.57 | 5.57 |
| 407.56 | 4.56 | 4.56 |
| 347.51 | 4.54 | 4.54 |