Basic Information
ID: ALA4627422
Type: Binding
Description: Inhibition of human P2X7 expressed in human HEK293 cells assessed as reduction in BzATP-stimulated TO-PRO-3 incorporation at 10 uM preincubated with compound and TO-PRO-3 for 15 mins prior to BzATP addition and measured after 1 hr by Fluo-3AM dye based flow cytometry relative to control
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: P2X purinoceptor 7(ALA4805)
Document: ALA4627246
Inhibition of human P2X7 expressed in human HEK293 cells assessed as reduction in BzATP-stimulated TO-PRO-3 incorporation at 10 uM preincubated with compound and TO-PRO-3 for 15 mins prior to BzATP addition and measured after 1 hr by Fluo-3AM dye based flow cytometry relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4627422
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 267.71 | 2.00 | 2.00 |
| 334.73 | 2.60 | 2.60 |
| 145.11 | -0.73 | -0.73 |
| 301.17 | 2.23 | 2.23 |
| 143.14 | -0.56 | -0.56 |
| 128.13 | -1.25 | -1.25 |
| 156.19 | -0.65 | -0.65 |
| 328.42 | 0.92 | 0.92 |
| 248.28 | 0.59 | 0.59 |
| 209.20 | 0.95 | 0.95 |
| 384.26 | 1.71 | 1.71 |
| 316.14 | 1.33 | 1.33 |
| 143.14 | -0.70 | -0.70 |
| 411.72 | 4.45 | 4.45 |
| 218.26 | 0.58 | 0.58 |
| 294.31 | 0.93 | 0.93 |
| 247.29 | 1.66 | 1.66 |
| 131.09 | -0.82 | -0.82 |
| 267.71 | 2.00 | 2.00 |
| 320.70 | 2.25 | 2.25 |
| 278.31 | 0.60 | 0.60 |
| 219.24 | 1.35 | 1.35 |
| 308.33 | 0.61 | 0.61 |
| 218.26 | 1.21 | 1.21 |
| 157.17 | 0.37 | 0.37 |
| 302.16 | 2.66 | 2.66 |
| 370.26 | 3.26 | 3.26 |
| 210.28 | 0.71 | 0.71 |
| 249.27 | 1.36 | 1.36 |
| 270.29 | 1.90 | 1.90 |
| 353.21 | 3.40 | 3.40 |
| 397.31 | 2.23 | 2.23 |
| 263.29 | 1.36 | 1.36 |
| 273.12 | 2.21 | 2.21 |
| 369.27 | 3.72 | 3.72 |
| 234.25 | 0.91 | 0.91 |
| 204.23 | 0.90 | 0.90 |
| 252.25 | 1.05 | 1.05 |
| 278.26 | 1.26 | 1.26 |
| 342.44 | 0.96 | 0.96 |
| 232.28 | 1.14 | 1.14 |
| 157.17 | -0.22 | -0.22 |
| 398.27 | 3.31 | 3.31 |
| 225.27 | 1.42 | 1.42 |
| 215.32 | ||
| 370.26 | 3.26 | 3.26 |
| 312.16 | 2.11 | 2.11 |
| 349.22 | 4.13 | 4.13 |
| 253.69 | 2.01 | 2.01 |
| 342.23 | 1.94 | 1.94 |
| 387.22 | 2.51 | 2.51 |
| 205.22 | 0.30 | 0.30 |
| 479.43 | 3.61 | 3.61 |
| 397.69 | 4.46 | 4.46 |
| 256.26 | -0.03 | -0.03 |
| 287.24 | 2.37 | 2.37 |
| 404.47 | 0.95 | 0.95 |
| 253.69 | 2.01 | 2.01 |
| 301.17 | 1.93 | 1.93 |
| 342.44 | 1.48 | 1.48 |
| 383.30 | 4.43 | 4.43 |
| 334.73 | 2.60 | 2.60 |
| 252.70 | 1.23 | 1.23 |
| 232.28 | 1.14 | 1.14 |
| 233.27 | 1.35 | 1.35 |
| 377.27 | 3.80 | 3.80 |
| 378.25 | 4.25 | 4.25 |
| 432.13 | 5.11 | 5.11 |
| 309.37 | 2.94 | 2.94 |
| 232.28 | 1.27 | 1.27 |
| 369.27 | 3.87 | 3.87 |
| 264.28 | 0.92 | 0.92 |
| 220.23 | 0.75 | 0.75 |
| 320.70 | 2.25 | 2.25 |
| 303.36 | 0.65 | 0.65 |
| 244.25 | 1.23 | 1.23 |
| 222.29 | 0.57 | 0.57 |
| 287.15 | 1.89 | 1.89 |
| 363.24 | 3.81 | 3.81 |
| 364.23 | 3.20 | 3.20 |
| 367.40 | 2.44 | 2.44 |
| 371.25 | 3.70 | 3.70 |
| 264.28 | 0.92 | 0.92 |
| 431.24 | 4.82 | 4.82 |
| 287.36 | 1.20 | 1.20 |
| 288.13 | 2.66 | 2.66 |
| 288.13 | 2.66 | 2.66 |
| 402.83 | 4.23 | 4.23 |
| 219.24 | -0.02 | -0.02 |
| 287.36 | 1.20 | 1.20 |
| 353.21 | 3.40 | 3.40 |
| 143.14 | -0.26 | -0.26 |
| 248.28 | 0.59 | 0.59 |
| 224.30 | 0.96 | 0.96 |
| 369.27 | 3.87 | 3.87 |
| 356.21 | 1.35 | 1.35 |
| 212.29 | 0.96 | 0.96 |
| 356.25 | 2.33 | 2.33 |
| 232.28 | 0.62 | 0.62 |
| 414.29 | 4.35 | 4.35 |