Basic Information
ID: ALA4668463
Type: Binding
Description: Allosteric inhibition of IRS1_pY1172(dPEG8)pY1222 activated-human full length SHP2 (Met1 to Leu525 residues) expressed in Escherichia coli BL21 Star (DE3) cells using DiFMUP as substrate preincubated for 30 to 60 mins followed by substrate addition and measured after 30 mins by fluorescence method
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4668463
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 432.87 | 4.13 | 4.13 |
| 446.85 | 3.82 | 3.82 |
| 402.84 | 4.12 | 4.12 |
| 573.99 | 3.82 | 3.82 |