Basic Information
ID: ALA4668675
Type: Binding
Description: Inhibition of NLRP3 in mouse J774A.1 cells assessed as inhibition of LPS and nigerecin-induced IL-1beta production pre-stimulated with LPS for 5 hrs followed by compound treatment for 30 mins and then nigericin addition for 45 mins by ELISA
Format: BAO_0000219
Organism: Mus musculus
Cell type: J774.A1
Target: NACHT, LRR and PYD domains-containing protein 3(ALA3779755)
Document: ALA4665686
Inhibition of NLRP3 in mouse J774A.1 cells assessed as inhibition of LPS and nigerecin-induced IL-1beta production pre-stimulated with LPS for 5 hrs followed by compound treatment for 30 mins and then nigericin addition for 45 mins by ELISA: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4668675
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 761.02 | 12.27 | 12.27 |
| 497.76 | 9.59 | 9.59 |