Basic Information
ID: ALA4669548
Type: Binding
Description: Corrector activity at CFTR F508del mutant (unknown origin) expressed in forskolin/VX-770-stimulated human CFBE41o- cells co-expressing HS-YFP assessed as increase in iodide influx measuring HS-YFP quenching at 2 to 10 uM incubated for 24 hrs by fluorescent method
Format: BAO_0000219
Organism: Homo sapiens
Cell type: CFBE41o-
Target: Cystic fibrosis transmembrane conductance regulator(ALA4051)
Document: ALA4665741
Corrector activity at CFTR F508del mutant (unknown origin) expressed in forskolin/VX-770-stimulated human CFBE41o- cells co-expressing HS-YFP assessed as increase in iodide influx measuring HS-YFP quenching at 2 to 10 uM incubated for 24 hrs by fluorescent method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4669548
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 290.34 | 2.44 | 2.44 |
| 296.74 | 2.68 | 2.68 |
| 408.48 | 2.94 | 2.94 |
| 380.42 | 2.53 | 2.53 |
| 444.29 | 3.52 | 3.52 |
| 324.79 | 3.09 | 3.09 |
| 380.42 | 2.46 | 2.46 |
| 318.40 | 2.92 | 2.92 |
| 262.29 | 2.02 | 2.02 |
| 352.84 | 3.57 | 3.57 |
| 324.79 | 3.15 | 3.15 |
| 352.37 | 2.05 | 2.05 |
| 388.19 | 2.63 | 2.63 |
| 416.24 | 3.11 | 3.11 |
| 290.34 | 2.50 | 2.50 |
| 416.24 | 3.04 | 3.04 |