Basic Information
ID: ALA4671068
Type: Functional
Description: Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium mobilization preincubated for 140 secs and treated with EC20 L-AP4 for 125 secs and followed by subsequent addition of EC80 L-AP4 by Fluo-4-AM dye based fluorescence assay
Organism: Rattus norvegicus
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA4671068
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 418.47 | 3.74 | 3.74 |
| 432.50 | 3.99 | 3.99 |
| 417.49 | 3.41 | 3.41 |
| 402.47 | 4.50 | 4.50 |
| 436.46 | 3.88 | 3.88 |
| 450.49 | 4.13 | 4.13 |
| 380.40 | 3.72 | 3.72 |
| 398.39 | 3.86 | 3.86 |
| 408.45 | 4.50 | 4.50 |
| 362.41 | 3.58 | 3.58 |
| 431.52 | 3.80 | 3.80 |
| 398.39 | 4.17 | 4.17 |
| 398.44 | 3.76 | 3.76 |
| 390.46 | 4.36 | 4.36 |
| 366.37 | 3.42 | 3.42 |
| 399.43 | 3.15 | 3.15 |
| 383.42 | 3.72 | 3.72 |
| 420.46 | 4.64 | 4.64 |
| 451.50 | 4.81 | 4.81 |
| 365.43 | 3.58 | 3.58 |
| 398.44 | 3.76 | 3.76 |
| 348.38 | 3.28 | 3.28 |
| 380.40 | 3.72 | 3.72 |
| 380.40 | 3.72 | 3.72 |
| 416.38 | 4.31 | 4.31 |
| 401.49 | 4.17 | 4.17 |
| 415.52 | 4.56 | 4.56 |