Basic Information
ID: ALA4672125
Type: Binding
Description: Inhibition of KEAP1 interaction with Nrf2 in human SH-SY5Y. cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured after 18 hrs by bright-Glo luciferase assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: SH-SY5Y
Target: Kelch-like ECH-associated protein 1(ALA2069156)
Document: ALA4665857
Inhibition of KEAP1 interaction with Nrf2 in human SH-SY5Y. cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured after 18 hrs by bright-Glo luciferase assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4672125
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 2290.53 | ||
| 1980.13 | ||
| 762.70 | -5.81 | -5.81 |
| 871.83 | -5.61 | -5.61 |
| 3113.59 | ||
| 2426.68 | ||
| 2186.45 | ||
| 3319.91 | ||
| 2633.00 | ||
| 954.92 | -5.94 | -5.94 |
| 2305.65 | ||
| 2324.65 | ||
| 2511.97 | ||
| 728.68 | -3.73 | -3.73 |
| 873.85 | -5.39 | -5.39 |
| 909.93 | -5.56 | -5.56 |
| 902.84 | -7.05 | -7.05 |
| 912.84 | -7.11 | -7.11 |
| 2266.51 | ||
| 703.63 | -5.30 | -5.30 |
| 954.92 | -5.94 | -5.94 |
| 3089.56 | ||
| 1956.11 | ||
| 916.87 | -6.66 | -6.66 |
| 888.82 | -7.44 | -7.44 |
| 2496.85 | ||
| 1623.79 | ||
| 1599.76 | ||
| 2402.65 | ||
| 1830.11 | ||
| 826.79 | -4.69 | -4.69 |
| 728.68 | -3.73 | -3.73 |
| 926.87 | -6.72 | -6.72 |
| 717.66 | -4.92 | -4.92 |