Basic Information
ID: ALA4673834
Type: Binding
Description: Inhibition of recombinant wild-type human COMT expressed in Escherichia coli BL21 using 4-nitrocatechol-Alexa488 as substrate in presence of cofactor SAM preincubated for 1 min followed by substrate addition and measured every 60 sec up to 180 times by fluorescence based microtiter plate reader analysis
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4673834
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 227.29 | 3.20 | 3.20 |
| 241.32 | 3.51 | 3.51 |
| 179.25 | 2.15 | 2.15 |
| 299.40 | 3.75 | 3.75 |
| 207.30 | 2.71 | 2.71 |
| 205.29 | 2.72 | 2.72 |
| 193.27 | 2.40 | 2.40 |
| 269.37 | 3.74 | 3.74 |
| 313.43 | 4.31 | 4.31 |
| 297.43 | 4.69 | 4.69 |
| 255.35 | 3.82 | 3.82 |
| 283.40 | 4.30 | 4.30 |
| 255.35 | 3.43 | 3.43 |
| 283.40 | 4.30 | 4.30 |
| 325.44 | 4.24 | 4.24 |
| 255.35 | 3.82 | 3.82 |
| 295.41 | 4.23 | 4.23 |
| 349.46 | 4.14 | 4.14 |
| 283.40 | 4.30 | 4.30 |
| 176.22 | 1.60 | 1.60 |
| 345.47 | 5.41 | 5.41 |
| 212.26 | 2.34 | 2.34 |
| 212.26 | 2.34 | 2.34 |
| 283.40 | 3.94 | 3.94 |
| 297.43 | 4.48 | 4.48 |
| 313.43 | 4.31 | 4.31 |
| 297.43 | 4.33 | 4.33 |