Basic Information
ID: ALA4676663
Type: ADME
Description: Inhibition of N-terminal GST-tagged human PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells using histone mixture (H2A and H2B) and biotinylated NAD+ as substrate in presence of activated DNA incubated for 60 mins by chemiluminescence assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: Sf9
Target: Poly [ADP-ribose] polymerase 2(ALA5366)
Document: ALA4673259
Inhibition of N-terminal GST-tagged human PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells using histone mixture (H2A and H2B) and biotinylated NAD+ as substrate in presence of activated DNA incubated for 60 mins by chemiluminescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4676663
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 434.47 | 2.35 | 2.35 |
| 323.37 | 2.98 | 2.98 |
| 380.36 | 2.63 | 2.63 |
| 411.51 | 3.35 | 3.35 |
| 398.47 | 2.56 | 2.56 |
| 411.51 | 3.35 | 3.35 |
| 405.48 | 2.88 | 2.88 |
| 447.49 | 3.63 | 3.63 |
| 429.50 | 3.49 | 3.49 |
| 447.49 | 3.63 | 3.63 |
| 397.48 | 3.16 | 3.16 |
| 429.50 | 3.49 | 3.49 |
| 398.46 | 3.14 | 3.14 |
| 437.52 | 2.36 | 2.36 |
| 387.49 | 2.74 | 2.74 |
| 415.47 | 3.30 | 3.30 |
| 423.49 | 2.10 | 2.10 |