Basic Information
ID: ALA4677367
Type: ADME
Description: Prodrug conversion in mouse liver microsomes assessed as CYP450-mediated 4-Propyl-1-thioxo-2,4-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-5(1H)-one formation at 20 uM preincubated for 3 mins followed by NADPH addition and measured after 60 mins by LC-MS/MS analysis
Format: BAO_0000251
Organism: Mus musculus
Tissue: Liver
Subcellular Fraction: Microsomes
Target: Unchecked(ALA612545)
Document: ALA4673282
Prodrug conversion in mouse liver microsomes assessed as CYP450-mediated 4-Propyl-1-thioxo-2,4-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-5(1H)-one formation at 20 uM preincubated for 3 mins followed by NADPH addition and measured after 60 mins by LC-MS/MS analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4677367
Drug metabolism
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 274.35 | 2.18 | 2.18 |