Basic Information
ID: ALA4677385
Type: Binding
Description: Inhibition of biotin-Ahx-CETFDPPLHSpTAI-NH2 binding to recombinant human full-length HA-EGFP-tagged Plk1 PBD expressed in HEK293A cells preincubated for 30 mins followed by biotin-Ahx-CETFDPPLHSpTAI-NH2 addition and measured after 1 hr by 3,3',5,5'-tetramethylbenzidine substrate based ELISA
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293-A
Target: Serine/threonine-protein kinase PLK1(ALA3024)
Document: ALA4673282
Inhibition of biotin-Ahx-CETFDPPLHSpTAI-NH2 binding to recombinant human full-length HA-EGFP-tagged Plk1 PBD expressed in HEK293A cells preincubated for 30 mins followed by biotin-Ahx-CETFDPPLHSpTAI-NH2 addition and measured after 1 hr by 3,3',5,5'-tetramethylbenzidine substrate based ELISA: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4677385
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 274.35 | 2.13 | 2.13 |
| 260.32 | 1.74 | 1.74 |
| 288.38 | 2.52 | 2.52 |
| 290.35 | 1.37 | 1.37 |
| 258.31 | 1.52 | 1.52 |
| 288.38 | 2.38 | 2.38 |
| 322.39 | 2.94 | 2.94 |
| 304.38 | 1.76 | 1.76 |
| 675.63 | -2.48 | -2.48 |
| 399.52 | 3.43 | 3.43 |
| 448.29 | 3.55 | 3.55 |
| 345.43 | 1.93 | 1.93 |
| 397.44 | 2.67 | 2.67 |
| 578.67 | 3.37 | 3.37 |
| 326.36 | 2.89 | 2.89 |
| 371.42 | 0.79 | 0.79 |
| 343.46 | 2.64 | 2.64 |
| 347.42 | 2.33 | 2.33 |
| 294.31 | 1.23 | 1.23 |
| 365.85 | 2.27 | 2.27 |
| 307.35 | 1.41 | 1.41 |
| 374.83 | 3.74 | 3.74 |
| 322.34 | 2.73 | 2.73 |
| 260.32 | 2.29 | 2.29 |
| 323.38 | 2.34 | 2.34 |
| 578.67 | 3.37 | 3.37 |
| 290.32 | 2.43 | 2.43 |
| 279.30 | 0.80 | 0.80 |
| 264.29 | 1.87 | 1.87 |
| 400.37 | 3.11 | 3.11 |
| 362.43 | 1.09 | 1.09 |
| 340.38 | 3.09 | 3.09 |
| 345.43 | 2.25 | 2.25 |
| 246.29 | 1.73 | 1.73 |
| 459.59 | 4.20 | 4.20 |
| 293.33 | 1.19 | 1.19 |
| 341.37 | 2.48 | 2.48 |
| 293.33 | 1.19 | 1.19 |
| 341.37 | 2.48 | 2.48 |
| 332.28 | 2.80 | 2.80 |
| 344.26 | 1.02 | 1.02 |
| 419.48 | 3.10 | 3.10 |
| 352.85 | 3.18 | 3.18 |
| 448.52 | 2.40 | 2.40 |
| 345.43 | 2.01 | 2.01 |
| 348.74 | 3.31 | 3.31 |
| 383.40 | 2.58 | 2.58 |
| 506.60 | 3.44 | 3.44 |
| 374.83 | 3.74 | 3.74 |
| 340.38 | 3.09 | 3.09 |
| 306.33 | 1.58 | 1.58 |
| 345.43 | 1.87 | 1.87 |
| 322.39 | 2.95 | 2.95 |
| 343.43 | 2.79 | 2.79 |
| 323.38 | 2.34 | 2.34 |
| 496.57 | 0.75 | 0.75 |
| 725.84 | 1.37 | 1.37 |
| 347.42 | 2.33 | 2.33 |
| 518.62 | 3.44 | 3.44 |
| 401.29 | 3.71 | 3.71 |
| 335.36 | 1.37 | 1.37 |
| 393.40 | 1.22 | 1.22 |
| 336.42 | 3.01 | 3.01 |
| 349.39 | 1.18 | 1.18 |
| 422.44 | 0.54 | 0.54 |
| 418.50 | 1.87 | 1.87 |
| 378.46 | 3.47 | 3.47 |
| 442.50 | 0.42 | 0.42 |
| 365.46 | 3.02 | 3.02 |
| 640.74 | 2.33 | 2.33 |
| 371.51 | 3.28 | 3.28 |
| 343.41 | 1.92 | 1.92 |
| 669.73 | 0.12 | 0.12 |
| 321.34 | 0.98 | 0.98 |
| 326.36 | 2.89 | 2.89 |
| 336.42 | 3.26 | 3.26 |
| 354.41 | 3.48 | 3.48 |
| 294.77 | 2.77 | 2.77 |
| 540.62 | 0.77 | 0.77 |
| 323.38 | 2.34 | 2.34 |
| 345.47 | 2.89 | 2.89 |
| 290.32 | 2.26 | 2.26 |
| 404.47 | 1.49 | 1.49 |
| 406.49 | 1.87 | 1.87 |
| 323.33 | 2.01 | 2.01 |
| 341.37 | 2.48 | 2.48 |
| 321.38 | 1.97 | 1.97 |
| 340.38 | 3.09 | 3.09 |
| 379.45 | 2.91 | 2.91 |
| 382.41 | 4.06 | 4.06 |
| 278.31 | 2.26 | 2.26 |
| 407.50 | 2.79 | 2.79 |
| 478.55 | 1.80 | 1.80 |
| 357.39 | 0.40 | 0.40 |
| 331.40 | 1.62 | 1.62 |
| 389.46 | 2.54 | 2.54 |
| 317.42 | 2.02 | 2.02 |
| 308.32 | 2.43 | 2.43 |
| 314.29 | 2.66 | 2.66 |
| 596.68 | 2.32 | 2.32 |