Basic Information
ID: ALA4677731
Type: Binding
Description: Displacement of (S)-N-(2-(N-(3-biphenyl-4-ylcarboxamido-4-(hydroxyamino)-4-oxobutyl)sulfamoyl)ethyl)-3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxamide fluorescent probe from histidine tagged Pseudomonas aeruginosa LpxC (1-303) expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of fluorscein probe measured after 2 hrs by fluorescence polarization assay
Organism: Pseudomonas aeruginosa
Activity Charts
Bioactivity
Activity Types for Assay ALA4677731
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 206.68 | 2.78 | 2.78 |
| 220.70 | 3.17 | 3.17 |
| 236.70 | 3.01 | 3.01 |
| 234.73 | 3.56 | 3.56 |
| 264.20 | 0.84 | 0.84 |
| 340.32 | 1.29 | 1.29 |
| 264.20 | 0.84 | 0.84 |
| 292.38 | 3.85 | 3.85 |
| 293.33 | 2.37 | 2.37 |
| 263.22 | 0.81 | 0.81 |
| 278.36 | 3.65 | 3.65 |
| 292.21 | 1.33 | 1.33 |
| 234.18 | 1.48 | 1.48 |
| 341.31 | 0.40 | 0.40 |
| 316.40 | 3.58 | 3.58 |
| 252.70 | 1.98 | 1.98 |
| 250.73 | 2.66 | 2.66 |
| 326.30 | 0.90 | 0.90 |
| 302.38 | 3.38 | 3.38 |
| 236.70 | 2.64 | 2.64 |
| 250.73 | 2.83 | 2.83 |
| 306.41 | 4.24 | 4.24 |
| 264.76 | 3.22 | 3.22 |
| 330.43 | 3.97 | 3.97 |
| 269.30 | 2.64 | 2.64 |
| 218.26 | 1.32 | 1.32 |