Basic Information
ID: ALA4678651
Type: Binding
Description: Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 pre-incubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 4.23 +/- 0.6 uM)
Organism: Homo sapiens
Cell type: SW-620
Activity Charts
Bioactivity
Activity Types for Assay ALA4678651
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 454.61 | 5.09 | 5.09 |
| 524.05 | 6.65 | 6.65 |
| 401.50 | 4.65 | 4.65 |
| 477.55 | 4.37 | 4.37 |
| 387.47 | 4.34 | 4.34 |
| 431.48 | 4.04 | 4.04 |
| 405.46 | 4.48 | 4.48 |
| 365.44 | 4.61 | 4.61 |
| 421.92 | 5.00 | 5.00 |
| 412.48 | 4.22 | 4.22 |
| 466.37 | 5.11 | 5.11 |
| 374.43 | 3.25 | 3.25 |
| 485.62 | 4.10 | 4.10 |
| 444.33 | 5.37 | 5.37 |
| 417.50 | 4.35 | 4.35 |
| 455.97 | 6.48 | 6.48 |
| 393.45 | 4.29 | 4.29 |
| 379.46 | 4.92 | 4.92 |
| 391.46 | 3.38 | 3.38 |
| 403.47 | 4.05 | 4.05 |
| 410.43 | 4.52 | 4.52 |
| 433.43 | 5.63 | 5.63 |
| 423.45 | 4.62 | 4.62 |
| 399.88 | 5.26 | 5.26 |
| 444.33 | 5.37 | 5.37 |
| 437.92 | 4.70 | 4.70 |
| 329.40 | 3.82 | 3.82 |
| 395.46 | 4.62 | 4.62 |
| 393.49 | 5.42 | 5.42 |
| 415.50 | 5.76 | 5.76 |
| 411.49 | 4.33 | 4.33 |
| 419.49 | 4.79 | 4.79 |
| 417.50 | 4.35 | 4.35 |
| 379.46 | 4.86 | 4.86 |
| 515.99 | 5.25 | 5.25 |
| 317.39 | 3.82 | 3.82 |
| 444.33 | 5.37 | 5.37 |
| 393.49 | 5.04 | 5.04 |
| 471.47 | 5.24 | 5.24 |
| 383.43 | 4.75 | 4.75 |
| 405.46 | 4.48 | 4.48 |
| 455.47 | 5.36 | 5.36 |
| 313.36 | 3.04 | 3.04 |
| 419.49 | 4.79 | 4.79 |
| 410.43 | 4.52 | 4.52 |
| 429.51 | 4.55 | 4.55 |
| 469.53 | 4.76 | 4.76 |
| 315.38 | 3.59 | 3.59 |
| 456.36 | 5.65 | 5.65 |
| 405.46 | 4.48 | 4.48 |
| 439.91 | 5.14 | 5.14 |
| 379.46 | 4.65 | 4.65 |
| 434.33 | 5.91 | 5.91 |
| 441.44 | 4.76 | 4.76 |