Basic Information
ID: ALA4679434
Type: Binding
Description: Inhibition of human liver mitochondrial KMO by measuring the 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis
Format: BAO_0000252
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Mitochondria
Target: Kynurenine 3-monooxygenase(ALA2145)
Document: ALA4673377
Inhibition of human liver mitochondrial KMO by measuring the 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4679434
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 290.71 | 3.04 | 3.04 |
| 408.53 | 4.24 | 4.24 |
| 375.43 | 3.83 | 3.83 |
| 380.47 | 3.25 | 3.25 |
| 423.54 | 3.61 | 3.61 |
| 394.50 | 3.85 | 3.85 |