Basic Information
ID: ALA4679436
Type: Binding
Description: Inhibition of mouse liver mitochondrial KMO by measuring the 3-HK metabolite formation using L-kynurenine as substrate preincubated for 5 mins followed by substate addition and measured after 30 mins by LC-MS/MS analysis
Organism: Mus musculus
Tissue: Liver
Subcellular Fraction: Mitochondria
Activity Charts
Bioactivity
Activity Types for Assay ALA4679436
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 290.71 | 3.04 | 3.04 |
| 355.42 | 3.26 | 3.26 |
| 408.53 | 4.24 | 4.24 |
| 376.44 | 3.80 | 3.80 |
| 375.43 | 3.83 | 3.83 |
| 368.46 | 3.32 | 3.32 |
| 368.46 | 3.32 | 3.32 |
| 380.47 | 3.25 | 3.25 |
| 368.46 | 3.32 | 3.32 |
| 410.50 | 3.09 | 3.09 |
| 388.88 | 3.66 | 3.66 |
| 388.88 | 3.66 | 3.66 |
| 376.44 | 3.80 | 3.80 |
| 423.54 | 3.61 | 3.61 |
| 353.45 | 3.82 | 3.82 |
| 394.50 | 3.85 | 3.85 |
| 388.88 | 3.66 | 3.66 |
| 378.46 | 3.74 | 3.74 |
| 423.54 | 3.00 | 3.00 |
| 359.84 | 3.91 | 3.91 |