Basic Information
ID: ALA4681356
Type: Binding
Description: Allosteric inhibition of C-terminal His-tagged recombinant human HDAC3 expressed in Sf9 cells pre-incubated for 2 hrs before acetylated lysine-aminomethyl coumarin-BOC addition and measured after 2 hrs by fluorescence based assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: Sf9
Target: Histone deacetylase 3(ALA1829)
Document: ALA4680089
Allosteric inhibition of C-terminal His-tagged recombinant human HDAC3 expressed in Sf9 cells pre-incubated for 2 hrs before acetylated lysine-aminomethyl coumarin-BOC addition and measured after 2 hrs by fluorescence based assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4681356
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 337.42 | 2.66 | 2.66 |
| 232.28 | 2.47 | 2.47 |
| 311.39 | 2.26 | 2.26 |
| 353.47 | 3.43 | 3.43 |
| 242.32 | 2.87 | 2.87 |
| 242.32 | 2.87 | 2.87 |
| 222.29 | 1.73 | 1.73 |
| 284.36 | 3.51 | 3.51 |
| 311.39 | 2.26 | 2.26 |
| 297.36 | 1.87 | 1.87 |
| 193.25 | 1.12 | 1.12 |
| 218.30 | 2.12 | 2.12 |
| 365.36 | 2.80 | 2.80 |
| 409.57 | 4.99 | 4.99 |
| 381.52 | 4.21 | 4.21 |
| 351.45 | 3.05 | 3.05 |
| 268.36 | 3.39 | 3.39 |
| 182.22 | 1.31 | 1.31 |
| 309.37 | 2.74 | 2.74 |
| 220.32 | 2.04 | 2.04 |
| 323.40 | 2.43 | 2.43 |
| 379.50 | 3.83 | 3.83 |
| 337.42 | 2.65 | 2.65 |
| 323.40 | 2.27 | 2.27 |
| 339.44 | 3.04 | 3.04 |
| 325.41 | 2.65 | 2.65 |
| 365.48 | 3.44 | 3.44 |
| 198.29 | 1.78 | 1.78 |
| 323.40 | 2.26 | 2.26 |
| 367.49 | 3.82 | 3.82 |