Basic Information
ID: ALA4681578
Type: ADME
Description: Inhibition of CYP2C9 in human liver microsomes assessed as reduction in tolbutamide 4-hydroxylase activity at 10 uM preincubated for 5 mins followed by addition of NADPH-regenerating system and measured after 15 mins by LC-MS/MS analysis relative to control
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA4681578
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 417.55 | 5.06 | 5.06 |
| 494.08 | 5.99 | 5.99 |
| 480.05 | 5.60 | 5.60 |
| 556.97 | 7.04 | 7.04 |
| 542.95 | 6.65 | 6.65 |
| 480.05 | 5.60 | 5.60 |