Binding affinity to ATM in wild type mouse assessed as free plasma concentration necessary to achieve 50% occupancy at 3 to 100 mg/kg, po dosed 1 hr b...

ID: ALA4682299

Type: Functional

Description: Binding affinity to ATM in wild type mouse assessed as free plasma concentration necessary to achieve 50% occupancy at 3 to 100 mg/kg, po dosed 1 hr before 5 Gy irradiation and measured 60 mins post-irradiation by biotin-tagged irreversible ADP probe based target engagement assay

Format: BAO_0000218

Organism: Mus musculus

Target:  Unchecked(ALA612545)

Document:  ALA4680114

Binding affinity to ATM in wild type mouse assessed as free plasma concentration necessary to achieve 50% occupancy at 3 to 100 mg/kg, po dosed 1 hr before 5 Gy irradiation and measured 60 mins post-irradiation by biotin-tagged irreversible ADP probe based target engagement assay: 1