Protac activity at E3 ubiquitin ligase/EGFR in human HCC827 cells assessed as increase in degradation of EGFR at 0.1 uM pretreated with (1-(6-(5-(4-(d...

ID: ALA4683930

Type: Binding

Description: Protac activity at E3 ubiquitin ligase/EGFR in human HCC827 cells assessed as increase in degradation of EGFR at 0.1 uM pretreated with (1-(6-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-ylamino)-2-(4-fluorophenylamino)pyrido[3,4-d]pyrimidin-4-yl)piperidin-4-yl)methanol and incubated for 6 hrs followed by compound addition and measured after 32 hrs by Western blot analysis

Format: BAO_0000219

Organism: Homo sapiens

Cell type: HCC827

Target:  Unchecked(ALA612545)

Document:  ALA4680163

Protac activity at E3 ubiquitin ligase/EGFR in human HCC827 cells assessed as increase in degradation of EGFR at 0.1 uM pretreated with (1-(6-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-ylamino)-2-(4-fluorophenylamino)pyrido[3,4-d]pyrimidin-4-yl)piperidin-4-yl)methanol and incubated for 6 hrs followed by compound addition and measured after 32 hrs by Western blot analysis: 1