Basic Information
ID: ALA4684495
Type: Binding
Description: Binding affinity to recombinant human N-terminal GST-tagged DOT1L (1 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as increase in melting temperature at 100 uM incubated for 1 min by 1,8-ANS probe based thermal shift assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Histone-lysine N-methyltransferase, H3 lysine-79 specific(ALA1795117)
Document: ALA4680176
Binding affinity to recombinant human N-terminal GST-tagged DOT1L (1 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as increase in melting temperature at 100 uM incubated for 1 min by 1,8-ANS probe based thermal shift assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4684495
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 506.52 | 0.23 | 0.23 |
| 462.51 | 1.40 | 1.40 |
| 512.55 | 0.29 | 0.29 |
| 481.44 | -0.27 | -0.27 |
| 524.89 | 2.75 | 2.75 |
| 517.55 | -0.06 | -0.06 |
| 468.47 | -0.24 | -0.24 |