Basic Information
ID: ALA4684499
Type: Binding
Description: Inhibition of recombinant human N-terminal GST-tagged DOT1L (1 to 420 residues) expressed in Escherichia coli BL21 (DE3) using nucleosome as substrate incubated for 1 hr in presence of [3H]-SAM by liquid scintillation counting method
Format: BAO_0000019
Organism: Homo sapiens
Target: Histone-lysine N-methyltransferase, H3 lysine-79 specific(ALA1795117)
Document: ALA4680176
Inhibition of recombinant human N-terminal GST-tagged DOT1L (1 to 420 residues) expressed in Escherichia coli BL21 (DE3) using nucleosome as substrate incubated for 1 hr in presence of [3H]-SAM by liquid scintillation counting method: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4684499
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 407.43 | 2.19 | 2.19 |
| 506.52 | 0.23 | 0.23 |
| 462.51 | 1.40 | 1.40 |
| 403.45 | 2.34 | 2.34 |
| 512.55 | 0.29 | 0.29 |
| 481.44 | -0.27 | -0.27 |
| 524.89 | 2.75 | 2.75 |
| 436.47 | 2.90 | 2.90 |
| 517.55 | -0.06 | -0.06 |
| 446.55 | 4.26 | 4.26 |
| 468.47 | -0.24 | -0.24 |