Basic Information
ID: ALA4684500
Type: Binding
Description: Inhibition of recombinant human N-terminal GST-tagged DOT1L (1 to 420 residues) expressed in Escherichia coli BL21 (DE3) using histone as substrate incubated for 1 hr by MTase-glo based luminescence assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Histone-lysine N-methyltransferase, H3 lysine-79 specific(ALA1795117)
Document: ALA4680176
Inhibition of recombinant human N-terminal GST-tagged DOT1L (1 to 420 residues) expressed in Escherichia coli BL21 (DE3) using histone as substrate incubated for 1 hr by MTase-glo based luminescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4684500
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 407.43 | 2.19 | 2.19 |
| 539.68 | 2.85 | 2.85 |
| 431.50 | 3.02 | 3.02 |
| 434.46 | 1.00 | 1.00 |
| 411.47 | 0.48 | 0.48 |
| 407.48 | 1.79 | 1.79 |
| 433.43 | 1.76 | 1.76 |
| 457.54 | 3.27 | 3.27 |
| 403.45 | 2.34 | 2.34 |
| 435.48 | 2.87 | 2.87 |
| 385.42 | 1.39 | 1.39 |
| 461.53 | 1.97 | 1.97 |
| 433.48 | 1.29 | 1.29 |
| 429.48 | 2.59 | 2.59 |
| 381.44 | 1.53 | 1.53 |