Basic Information
ID: ALA4684509
Type: Binding
Description: Inhibition of DOT1L in mouse bone marrow cell transformed with MLL-AF9 cells assessed as reduction in H3K79 methylation at 30 uM measured after 9 days by Western blot analysis relative to control
Format: BAO_0000221
Organism: Mus musculus
Cell type: Bone marrow cell
Target: Histone H3 methyltransferase DOT1 variant d(ALA4739691)
Document: ALA4680176
Inhibition of DOT1L in mouse bone marrow cell transformed with MLL-AF9 cells assessed as reduction in H3K79 methylation at 30 uM measured after 9 days by Western blot analysis relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4684509
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 461.53 | 1.97 | 1.97 |