Basic Information
ID: ALA4684512
Type: Binding
Description: Inhibition of DOT1L in mouse bone marrow cell transformed with MLL-AF9 cells assessed as reduction in H3K20me2 methylation at 1 to 30 uM measured after 6 days by Western blot analysis
Format: BAO_0000221
Organism: Mus musculus
Cell type: Bone marrow cell
Target: Histone H3 methyltransferase DOT1 variant d(ALA4739691)
Document: ALA4680176
Inhibition of DOT1L in mouse bone marrow cell transformed with MLL-AF9 cells assessed as reduction in H3K20me2 methylation at 1 to 30 uM measured after 6 days by Western blot analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4684512
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 461.53 | 1.97 | 1.97 |