Basic Information
ID: ALA4688263
Type: Binding
Description: Inhibition of exogenous human TNFalpha in HEK-Blue-CD40L cells assessed as reduction in TNF-alpha-induced NFkappaB activation incubated for 18 hrs by quanti-blue based SEAP assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK-Blue CD40L
Target: TNF-alpha(ALA1825)
Document: ALA4680302
Inhibition of exogenous human TNFalpha in HEK-Blue-CD40L cells assessed as reduction in TNF-alpha-induced NFkappaB activation incubated for 18 hrs by quanti-blue based SEAP assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4688263
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 437.91 | 5.28 | 5.28 |
| 437.91 | 5.28 | 5.28 |
| 436.92 | 5.88 | 5.88 |
| 423.52 | 4.58 | 4.58 |
| 471.36 | 6.54 | 6.54 |
| 419.92 | 5.14 | 5.14 |
| 350.43 | 5.53 | 5.53 |
| 454.91 | 6.02 | 6.02 |
| 471.58 | 5.83 | 5.83 |
| 454.91 | 6.02 | 6.02 |
| 464.97 | 6.52 | 6.52 |
| 404.90 | 5.18 | 5.18 |
| 521.00 | 4.86 | 4.86 |
| 471.36 | 6.54 | 6.54 |
| 461.93 | 5.76 | 5.76 |
| 436.92 | 5.88 | 5.88 |
| 418.93 | 5.75 | 5.75 |
| 436.92 | 5.88 | 5.88 |
| 432.96 | 6.24 | 6.24 |
| 434.94 | 7.09 | 7.09 |
| 471.36 | 6.54 | 6.54 |
| 384.87 | 6.18 | 6.18 |
| 432.95 | 5.92 | 5.92 |
| 494.93 | 5.60 | 5.60 |
| 418.93 | 5.93 | 5.93 |
| 398.51 | 5.59 | 5.59 |
| 418.93 | 5.75 | 5.75 |
| 451.93 | 5.47 | 5.47 |
| 512.01 | 4.89 | 4.89 |
| 436.92 | 5.88 | 5.88 |
| 455.94 | 5.67 | 5.67 |
| 437.91 | 5.28 | 5.28 |
| 361.67 | 6.01 | 6.01 |
| 450.95 | 6.27 | 6.27 |
| 506.03 | 6.49 | 6.49 |
| 486.93 | 6.76 | 6.76 |
| 422.89 | 6.06 | 6.06 |