Basic Information
ID: ALA4688478
Type: Binding
Description: Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Fluo-4 AM dye based fluorescence analysis
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293T
Target: Transient receptor potential cation channel subfamily M member 8(ALA1075319)
Document: ALA4680310
Antagonist activity at human TRPM8 transfected in HEK293T cells assessed as reduction in menthol-induced calcium influx measured after 60 mins by Fluo-4 AM dye based fluorescence analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4688478
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 394.42 | 4.39 | 4.39 |
| 384.48 | 4.43 | 4.43 |
| 370.45 | 4.04 | 4.04 |
| 422.89 | 4.84 | 4.84 |
| 388.44 | 4.18 | 4.18 |
| 437.90 | 4.54 | 4.54 |
| 412.41 | 4.53 | 4.53 |
| 407.42 | 3.72 | 3.72 |
| 371.44 | 3.44 | 3.44 |
| 404.90 | 4.70 | 4.70 |
| 388.44 | 4.18 | 4.18 |
| 423.88 | 4.23 | 4.23 |
| 406.43 | 4.32 | 4.32 |
| 372.42 | 3.49 | 3.49 |
| 412.41 | 4.53 | 4.53 |
| 408.45 | 4.70 | 4.70 |
| 409.44 | 3.98 | 3.98 |
| 453.90 | 4.24 | 4.24 |
| 404.90 | 4.70 | 4.70 |
| 358.44 | 4.12 | 4.12 |
| 410.42 | 4.10 | 4.10 |
| 438.89 | 3.81 | 3.81 |