Basic Information
ID: ALA4688481
Type: ADME
Description: Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxymidazolam formation using midazolam as substrate at 10 uM preincubated with enzyme and NADPH followed by substrate addition and measured after 10 mins by HPLC/MS-MS analysis relative to control
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsomes
Target: Cytochrome P450 3A4(ALA340)
Document: ALA4680310
Inhibition of CYP3A4 in human liver microsomes assessed as reduction in 1'-hydroxymidazolam formation using midazolam as substrate at 10 uM preincubated with enzyme and NADPH followed by substrate addition and measured after 10 mins by HPLC/MS-MS analysis relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4688481
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 394.42 | 4.39 | 4.39 |
| 437.90 | 4.54 | 4.54 |
| 423.88 | 4.23 | 4.23 |
| 453.90 | 4.24 | 4.24 |
| 438.89 | 3.81 | 3.81 |