Basic Information
ID: ALA4689495
Type: Binding
Description: Inhibition of HPK1 in anti-CD3/anti-CD28-stimulated human T-cells assessed as inhibition of SLP76 phosphorylation preincubated for 1 hr followed by anti-CD3/CD28 stimulation for 30 mins by AlphaLISA assay
Format: BAO_0000221
Organism: Homo sapiens
Cell type: T cell
Target: Mitogen-activated protein kinase kinase kinase kinase 1(ALA5749)
Document: ALA4680358
Inhibition of HPK1 in anti-CD3/anti-CD28-stimulated human T-cells assessed as inhibition of SLP76 phosphorylation preincubated for 1 hr followed by anti-CD3/CD28 stimulation for 30 mins by AlphaLISA assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4689495
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 555.64 | 4.63 | 4.63 |
| 458.48 | 3.82 | 3.82 |
| 500.56 | 4.94 | 4.94 |
| 486.53 | 4.38 | 4.38 |
| 552.57 | 5.63 | 5.63 |
| 567.65 | 4.56 | 4.56 |
| 514.59 | 5.12 | 5.12 |
| 555.64 | 4.63 | 4.63 |
| 472.51 | 4.13 | 4.13 |
| 567.65 | 4.56 | 4.56 |
| 498.54 | 4.70 | 4.70 |
| 498.54 | 4.70 | 4.70 |
| 535.56 | 4.88 | 4.88 |
| 472.51 | 4.13 | 4.13 |