Basic Information
ID: ALA4701743
Type: Binding
Description: Inhibition of recombinant human full-length N-terminal His-tagged p110 alpha/p85 alpha expressed in baculovirus expression system using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by ADP HiLyte 647 tracer bound ADP2 antibody-Tb conjugate based HTRF assay
Format: BAO_0000019
Organism: Homo sapiens
Target: PI3-kinase p110-alpha/p85-alpha(ALA2111367)
Document: ALA4699485
Inhibition of recombinant human full-length N-terminal His-tagged p110 alpha/p85 alpha expressed in baculovirus expression system using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by ADP HiLyte 647 tracer bound ADP2 antibody-Tb conjugate based HTRF assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4701743
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 445.48 | 2.75 | 2.75 |
| 435.49 | 2.15 | 2.15 |
| 435.49 | 2.15 | 2.15 |
| 441.52 | 2.22 | 2.22 |
| 444.50 | 3.35 | 3.35 |
| 445.48 | 2.75 | 2.75 |
| 446.47 | 2.14 | 2.14 |
| 427.49 | 1.91 | 1.91 |
| 435.49 | 2.15 | 2.15 |
| 422.45 | 1.24 | 1.24 |
| 421.46 | 1.85 | 1.85 |
| 410.44 | 1.17 | 1.17 |
| 421.46 | 2.57 | 2.57 |