Inhibition of CYP2D6 in human liver microsomes using isoform-specific probe substrates preincubated for 5 mins followed by NADPH addition by LC-MS/MS ...

Basic Information

ID: ALA4701761

Type: ADME

Description: Inhibition of CYP2D6 in human liver microsomes using isoform-specific probe substrates preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysis

Format: BAO_0000251

Organism: Homo sapiens

Tissue: Liver

Subcellular Fraction: Microsomes

Target: Cytochrome P450 2D6(ALA289)

Document: ALA4699485

Inhibition of CYP2D6 in human liver microsomes using isoform-specific probe substrates preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysis: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4701761

IC50

Total(3)

Parent Molecular Weight	ALogP	Polar Surface Area
445.48	2.75	2.75
427.49	1.91	1.91
421.46	1.85	1.85

Parent Molecular Weight

ALogP

Polar Surface Area

445.48

2.75

427.49

1.91

421.46

1.85

Inhibition of CYP2D6 in human liver microsomes using isoform-specific probe substrates preincubated for 5 mins followed by NADPH addition by LC-MS/MS ...

Basic Information

Activity Charts

Compound Summary