Basic Information
ID: ALA4701823
Type: Binding
Description: Negative allosteric modulation of recombinant human GABA-A alpha5 expressed in HEK293 cells assessed as reduction in GABA-induced current at 1 uM relative to control
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA4701823
Efficacy
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 376.44 | 4.43 | 4.43 |
| 335.37 | 3.03 | 3.03 |
| 433.39 | 3.84 | 3.84 |
| 418.38 | 3.35 | 3.35 |
| 345.41 | 3.47 | 3.47 |
| 349.44 | 3.42 | 3.42 |
| 349.39 | 2.94 | 2.94 |
| 384.37 | 4.19 | 4.19 |
| 385.37 | 3.53 | 3.53 |
| 363.40 | 3.61 | 3.61 |
| 361.41 | 3.65 | 3.65 |
| 419.80 | 4.76 | 4.76 |
| 396.46 | 4.00 | 4.00 |
| 335.37 | 2.92 | 2.92 |
| 364.41 | 2.64 | 2.64 |
| 342.41 | 4.28 | 4.28 |
| 349.39 | 2.94 | 2.94 |
| 350.38 | 2.34 | 2.34 |
| 350.38 | 2.34 | 2.34 |
| 363.42 | 3.33 | 3.33 |
| 319.37 | 4.03 | 4.03 |
| 345.41 | 3.47 | 3.47 |
| 347.42 | 3.49 | 3.49 |
| 365.40 | 2.04 | 2.04 |
| 294.36 | 3.59 | 3.59 |
| 350.38 | 2.34 | 2.34 |
| 351.37 | 1.73 | 1.73 |
| 350.38 | 2.34 | 2.34 |
| 264.33 | 3.58 | 3.58 |
| 364.41 | 2.64 | 2.64 |