Basic Information
ID: ALA4701825
Type: ADME
Description: Negative allosteric modulation of recombinant human GABA-A alpha2 expressed in HEK293 cells assessed as reduction in GABA-induced current at 1 uM relative to control
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA4701825
Efficacy
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 321.38 | 3.54 | 3.54 |
| 381.41 | 3.39 | 3.39 |
| 433.39 | 3.84 | 3.84 |
| 345.41 | 3.47 | 3.47 |
| 349.39 | 2.94 | 2.94 |
| 384.37 | 4.19 | 4.19 |
| 385.37 | 3.53 | 3.53 |
| 363.40 | 3.61 | 3.61 |
| 361.41 | 3.65 | 3.65 |
| 419.80 | 4.76 | 4.76 |
| 396.46 | 4.00 | 4.00 |
| 335.37 | 2.92 | 2.92 |
| 364.41 | 2.64 | 2.64 |
| 342.41 | 4.28 | 4.28 |
| 349.39 | 2.94 | 2.94 |
| 350.38 | 2.34 | 2.34 |
| 350.38 | 2.34 | 2.34 |
| 319.37 | 4.03 | 4.03 |
| 324.38 | 3.60 | 3.60 |
| 345.41 | 3.47 | 3.47 |
| 365.40 | 2.04 | 2.04 |
| 294.36 | 3.59 | 3.59 |
| 350.38 | 2.34 | 2.34 |
| 350.38 | 2.34 | 2.34 |
| 367.38 | 3.08 | 3.08 |