Basic Information
ID: ALA4701889
Type: Binding
Description: Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY122 incubated for 30 mins by fluorescence based DIFMUP assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4701889
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 352.27 | 3.35 | 3.35 |
| 352.27 | 3.35 | 3.35 |
| 338.24 | 2.96 | 2.96 |
| 352.27 | 3.22 | 3.22 |
| 352.27 | 3.22 | 3.22 |
| 311.20 | 4.00 | 4.00 |
| 353.26 | 2.75 | 2.75 |
| 311.43 | 2.53 | 2.53 |
| 366.30 | 3.81 | 3.81 |
| 317.82 | 2.57 | 2.57 |
| 337.25 | 3.77 | 3.77 |
| 366.30 | 3.56 | 3.56 |
| 421.96 | 2.17 | 2.17 |
| 407.93 | 1.78 | 1.78 |
| 421.96 | 2.17 | 2.17 |
| 349.89 | 3.18 | 3.18 |
| 405.96 | 2.94 | 2.94 |
| 398.46 | 3.19 | 3.19 |
| 366.30 | 3.60 | 3.60 |
| 424.50 | 3.72 | 3.72 |
| 384.43 | 2.94 | 2.94 |
| 384.34 | 3.83 | 3.83 |
| 390.94 | 3.36 | 3.36 |
| 366.30 | 3.27 | 3.27 |
| 424.50 | 3.72 | 3.72 |
| 379.92 | 2.41 | 2.41 |
| 398.36 | 4.08 | 4.08 |
| 378.93 | 3.01 | 3.01 |
| 368.27 | 3.48 | 3.48 |