Inhibition of CYP2C9 in human liver microsomes at 10 uM using diclofenac as substrate preincubated for 5 mins followed by NADPH addition and measured ...

Basic Information

ID: ALA4707031

Type: ADME

Description: Inhibition of CYP2C9 in human liver microsomes at 10 uM using diclofenac as substrate preincubated for 5 mins followed by NADPH addition and measured after 20 mins by LC-MS/MS analysis relative to control

Format: BAO_0000251

Organism: Homo sapiens

Tissue: Liver

Subcellular Fraction: Microsomes

Target: Cytochrome P450 2C9(ALA3397)

Document: ALA4706476

Inhibition of CYP2C9 in human liver microsomes at 10 uM using diclofenac as substrate preincubated for 5 mins followed by NADPH addition and measured after 20 mins by LC-MS/MS analysis relative to control: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA4707031

Inhibition

Total(2)

Parent Molecular Weight	ALogP	Polar Surface Area
314.37	2.26	2.26
430.51	2.67	2.67

Parent Molecular Weight

ALogP

Polar Surface Area

314.37

2.26

430.51

2.67

Inhibition of CYP2C9 in human liver microsomes at 10 uM using diclofenac as substrate preincubated for 5 mins followed by NADPH addition and measured ...

Basic Information

Activity Charts

Compound Summary