Basic Information
ID: ALA4708323
Type: Binding
Description: Inhibition of Kaposi's sarcoma herpesvirus C-terminal His-tagged oligomerization deficient LANA DBD (1008 to 1146 residues) K1055E/K1138S/K1140D/K1141D/R1039Q/R1040Q/A1121E/K1109A/D1110A mutant expressed in Escherichia coli BL21(DE3) assessed as inhibition of LANA interaction with fluorescently-labelled viral DNA LBS2 probe preincubated with LANA-DBD for 60 mins followed by addition of DNA probe and measured after 90 mins by flourescence polarization assay
Organism: Human gammaherpesvirus 8
Activity Charts
Bioactivity
Activity Types for Assay ALA4708323
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 266.26 | 2.03 | 2.03 |
| 350.77 | 3.83 | 3.83 |
| 247.26 | 2.20 | 2.20 |
| 358.36 | 3.40 | 3.40 |
| 316.32 | 3.18 | 3.18 |
| 358.36 | 3.82 | 3.82 |
| 390.37 | 4.27 | 4.27 |
| 314.73 | 2.99 | 2.99 |
| 390.83 | 4.66 | 4.66 |
| 372.38 | 3.19 | 3.19 |
| 376.80 | 4.35 | 4.35 |
| 357.37 | 3.77 | 3.77 |
| 280.29 | 2.09 | 2.09 |
| 237.27 | 1.91 | 1.91 |
| 342.36 | 3.69 | 3.69 |
| 374.36 | 2.97 | 2.97 |
| 291.27 | 1.90 | 1.90 |
| 280.29 | 2.34 | 2.34 |
| 296.29 | 2.04 | 2.04 |
| 372.38 | 3.70 | 3.70 |
| 280.29 | 2.34 | 2.34 |
| 266.26 | 2.03 | 2.03 |
| 342.36 | 3.69 | 3.69 |
| 386.41 | 3.50 | 3.50 |
| 372.38 | 3.71 | 3.71 |
| 378.34 | 3.97 | 3.97 |
| 372.38 | 4.13 | 4.13 |
| 282.26 | 1.73 | 1.73 |
| 356.39 | 4.00 | 4.00 |
| 388.45 | 4.49 | 4.49 |
| 330.35 | 3.49 | 3.49 |
| 332.32 | 3.29 | 3.29 |
| 323.36 | 2.85 | 2.85 |
| 316.32 | 3.18 | 3.18 |
| 372.38 | 3.19 | 3.19 |
| 390.37 | 4.27 | 4.27 |
| 300.71 | 2.68 | 2.68 |
| 390.37 | 4.27 | 4.27 |