Basic Information
ID: ALA4708325
Type: Binding
Description: Inhibition of Kaposi's sarcoma herpesvirus C-terminal His-tagged oligomerization deficient LANA DBD (1008 to 1146 residues) K1055E/K1138S/K1140D/K1141D/R1039Q/R1040Q/A1121E/K1109A/D1110A mutant expressed in Escherichia coli BL21(DE3) assessed as inhibition of LANA interaction with fluorescently-labelled viral DNA LBS3 probe preincubated with LANA-DBD for 60 mins followed by addition of DNA probe and measured after 90 mins by flourescence polarization assay
Organism: Human gammaherpesvirus 8
Activity Charts
Bioactivity
Activity Types for Assay ALA4708325
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 266.26 | 2.03 | 2.03 |
| 350.77 | 3.83 | 3.83 |
| 358.36 | 3.82 | 3.82 |
| 376.80 | 4.35 | 4.35 |
| 342.36 | 3.69 | 3.69 |
| 386.41 | 3.50 | 3.50 |
| 372.38 | 3.71 | 3.71 |
| 330.35 | 3.49 | 3.49 |