Basic Information
ID: ALA4708504
Type: Binding
Description: Potency index, ratio of AG-221 IC50 to test compound IC50 for IDH2 R140Q mutant (unknown origin) assessed as reduction in NADPH consumption using alpha-ketoglutarate and NADPH as substrate preincubated with enzyme for 15 mins followed by substrate addition by fluorescence based assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4708504
Ratio IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 482.43 | 6.24 | 6.24 |
| 480.42 | 6.02 | 6.02 |