Basic Information
ID: ALA4709557
Type: Binding
Description: Inhibition of Keap1-Nrf2 protein-protein interaction in human HepG2 cells transfected with ARE-C8 assessed as activation of Nrf2-ARE transcriptional activity at 0.01 uM after 12 hrs by luciferase reporter gene assay relative to control
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HepG2
Target: Keap1/Nrf2(ALA3038498)
Document: ALA4706544
Inhibition of Keap1-Nrf2 protein-protein interaction in human HepG2 cells transfected with ARE-C8 assessed as activation of Nrf2-ARE transcriptional activity at 0.01 uM after 12 hrs by luciferase reporter gene assay relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4709557
FC
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 563.63 | 5.26 | 5.26 |
| 590.65 | 5.21 | 5.21 |
| 601.60 | 6.27 | 6.27 |
| 533.60 | 5.25 | 5.25 |
| 612.50 | 6.01 | 6.01 |
| 547.63 | 5.62 | 5.62 |
| 551.57 | 4.34 | 4.34 |
| 536.52 | 4.23 | 4.23 |
| 491.52 | 4.32 | 4.32 |
| 541.58 | 5.48 | 5.48 |
| 575.52 | 5.22 | 5.22 |
| 559.52 | 5.34 | 5.34 |
| 521.55 | 4.33 | 4.33 |
| 505.55 | 4.63 | 4.63 |
| 525.97 | 4.98 | 4.98 |
| 534.55 | 3.42 | 3.42 |
| 577.66 | 5.65 | 5.65 |
| 591.68 | 6.04 | 6.04 |
| 570.42 | 5.09 | 5.09 |
| 509.51 | 4.46 | 4.46 |
| 589.71 | 6.55 | 6.55 |
| 551.59 | 5.39 | 5.39 |
| 568.05 | 5.90 | 5.90 |
| 549.60 | 4.96 | 4.96 |
| 548.57 | 4.28 | 4.28 |