Assay Report Card

Basic Information

ID: ALA4710189

Type: Binding

Description: Inhibition of biotinylated 5-(4-((Z)-3-Carboxy-3-hydroxyacryloyl)-4-(4-chlorobenzyl)piperidine-1-carbonyl)-2-((13,35-dioxo-39-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazole-4-yl)-3,6,9,16,19,22,25,28,31-nonaoxa-12,34-diazanonatriacontyl)oxy)benzoic acid binding to Influenza A virus (A/California/07/2009(H1N1)) N-terminal GST-tagged polymerase acidic subunit N-terminal domain expressed in Escherichia coli BL21 (DE3) RIL cells measured after 120 mins by Alphascreen assay

Organism: Influenza A virus (A/California/07/2009(H1N1))

Activity Charts

Bioactivity

Activity Types for Assay ALA4710189

IC50

Total(58)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
232.24	1.42	1.42
270.24	2.58	2.58
270.24	2.58	2.58
302.24	1.99	1.99
288.25	2.22	2.22
304.25	1.19	1.19
242.27	3.23	3.23
372.37	3.50	3.50
368.39	3.37	3.37
302.24	1.99	1.99
286.24	2.28	2.28
286.24	2.28	2.28
354.31	-0.65	-0.65
286.24	2.28	2.28
482.44	2.36	2.36
458.38	2.23	2.23
306.27	1.25	1.25
518.56	6.38	6.38
318.24	1.69	1.69
220.18	1.02	1.02
270.24	2.58	2.58
401.87	2.73	2.73
358.35	3.20	3.20
290.27	1.55	1.55
300.27	2.59	2.59
307.26	-1.29	-1.29
308.33	3.84	3.84
340.33	3.25	3.25
396.44	4.46	4.46
482.44	2.40	2.40
316.26	2.29	2.29
290.27	1.55	1.55
254.24	2.87	2.87
270.24	2.58	2.58
270.24	2.58	2.58
448.38	-0.24	-0.24
302.24	1.99	1.99
448.38	-0.20	-0.20
432.38	0.09	0.09
448.38	-0.20	-0.20
434.35	0.10	0.10
464.38	0.19	0.19
254.24	2.87	2.87
270.24	2.58	2.58
413.90	4.26	4.26
290.27	1.55	1.55
222.15	0.62	0.62
372.37	3.50	3.50
320.25	0.89	0.89
483.50	2.98	2.98
480.47	2.06	2.06
285.25	2.02	2.02
318.24	0.66	0.66
301.25	1.72	1.72
306.27	1.75	1.75
195.17	-0.18	-0.18
346.34	1.92	1.92
286.24	2.28	2.28