Basic Information
ID: ALA4714711
Type: Binding
Description: Inhibition of recombinant human GST tagged LRRK2 G2019S mutant catalytic domain (970 to 2527 residues) expressed in baculovirus expression system using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by substrate addition and measured after 90 mins by TR-FRET based Lanthascreen assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Leucine-rich repeat serine/threonine-protein kinase 2(ALA1075104)
Document: ALA4706723
Inhibition of recombinant human GST tagged LRRK2 G2019S mutant catalytic domain (970 to 2527 residues) expressed in baculovirus expression system using fluorescein-labeled LRRKtide as substrate preincubated for 15 mins followed by substrate addition and measured after 90 mins by TR-FRET based Lanthascreen assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4714711
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 399.93 | 3.77 | 3.77 |
| 402.50 | 3.40 | 3.40 |
| 462.99 | 4.25 | 4.25 |
| 411.94 | 4.18 | 4.18 |
| 437.98 | 4.35 | 4.35 |
| 399.93 | 3.86 | 3.86 |