Basic Information
ID: ALA4718739
Type: Functional
Description: Potency index, ratio of IC50 of benznidazole to IC50 of compound for trypanocidal activity against Trypanosoma cruzi Tulahuen C4 amastigotes intra-peritoneally infected in BALB/C mouse assessed as reduction in spleen trypomastigotes treated day 4 post infection for 20 days
Format: BAO_0000218
Organism: Trypanosoma cruzi
Strain: Tulahuen C4
Target: Trypanosoma cruzi(ALA368)
Document: ALA4715756
Potency index, ratio of IC50 of benznidazole to IC50 of compound for trypanocidal activity against Trypanosoma cruzi Tulahuen C4 amastigotes intra-peritoneally infected in BALB/C mouse assessed as reduction in spleen trypomastigotes treated day 4 post infection for 20 days: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4718739
Ratio IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 329.24 | 1.52 | 1.52 |
| 348.32 | 2.36 | 2.36 |
| 339.31 | 2.62 | 2.62 |
| 373.76 | 3.27 | 3.27 |
| 357.30 | 2.76 | 2.76 |
| 323.31 | 2.49 | 2.49 |
| 353.34 | 2.40 | 2.40 |
| 367.37 | 2.79 | 2.79 |
| 348.71 | 2.13 | 2.13 |
| 353.34 | 3.01 | 3.01 |
| 346.28 | 2.01 | 2.01 |
| 371.33 | 3.15 | 3.15 |
| 337.34 | 2.88 | 2.88 |
| 387.78 | 3.66 | 3.66 |
| 329.24 | 1.87 | 1.87 |
| 362.73 | 2.52 | 2.52 |
| 332.25 | 1.62 | 1.62 |
| 362.35 | 2.75 | 2.75 |