Basic Information
ID: ALA4719946
Type: Functional
Description: Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction in DCG IV-induced inhibition of forskolin-stimulated cAMP accumulation preincubated for 20 mins followed by incubation with cAMP-d2 conjugate and anti-cAMP cryptate for 1 hr by HTRF assay relative to glutamate
Organism: Homo sapiens
Cell type: AV12
Activity Charts
Bioactivity
Activity Types for Assay ALA4719946
Efficacy
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 432.90 | 1.09 | 1.09 |
| 428.72 | 1.81 | 1.81 |
| 289.35 | -0.15 | -0.15 |
| 395.81 | 0.78 | 0.78 |
| 377.82 | 0.64 | 0.64 |
| 390.86 | 0.91 | 0.91 |
| 387.89 | 1.12 | 1.12 |
| 359.83 | 0.50 | 0.50 |
| 474.97 | 1.86 | 1.86 |
| 442.75 | 1.95 | 1.95 |
| 377.82 | 0.64 | 0.64 |
| 359.83 | 0.50 | 0.50 |
| 359.83 | 0.50 | 0.50 |
| 391.85 | 0.95 | 0.95 |
| 359.83 | 0.50 | 0.50 |
| 377.82 | 0.64 | 0.64 |