Basic Information
ID: ALA4721175
Type: Binding
Description: Inhibition of recombinant human N-terminal GST tagged EGFR L858R mutant (669 to 1210 residues) expressed in insect expression system using peptide as substrate incubated for 2 hrs followed by substrate addition and measured after 30 mins by TR-FRET assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA4721175
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 485.95 | 4.39 | 4.39 |
| 485.95 | 4.39 | 4.39 |
| 494.98 | 4.55 | 4.55 |
| 499.62 | 4.51 | 4.51 |
| 485.83 | 5.47 | 5.47 |
| 556.96 | 5.80 | 5.80 |
| 688.12 | 6.40 | 6.40 |
| 705.12 | 7.15 | 7.15 |
| 598.99 | 5.57 | 5.57 |
| 598.01 | 5.09 | 5.09 |
| 668.13 | 5.37 | 5.37 |
| 688.12 | 6.92 | 6.92 |
| 698.11 | 7.09 | 7.09 |
| 612.04 | 5.48 | 5.48 |
| 564.55 | 4.91 | 4.91 |
| 582.54 | 5.05 | 5.05 |
| 570.98 | 6.19 | 6.19 |
| 651.10 | 6.22 | 6.22 |
| 606.01 | 5.30 | 5.30 |
| 655.08 | 5.45 | 5.45 |
| 473.80 | 5.60 | 5.60 |
| 598.01 | 5.14 | 5.14 |
| 640.05 | 5.40 | 5.40 |
| 542.93 | 5.41 | 5.41 |