Basic Information
ID: ALA4721819
Type: Binding
Description: Covalent binding affinity to VAT1 at Cys residue in human NCI-H358 cells assessed as reduction of log2 H/L ratio for tryptic peptide CLVLTGFGGYDK incubated for 4 hrs followed by cell lysis and subsequently labelled with light thiol probe N-((S)-18-iodo-11-isopropyl-10,13,17-trioxo-3,6-dioxa-9,12,16-triazaoctadecyl)-6-((4R,5S)-5-methyl-2-oxoimidazolidin-4-yl)hexanamide and heavy thiol probe 4 for 1 hr under dark conditions followed by tryptic digestion for overnight and measured by discovery ABPP based nano LC-MS/MS analysis
Organism: Homo sapiens
Cell type: NCI-H358
Activity Charts
Bioactivity
Activity Types for Assay ALA4721819
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 430.84 | 3.77 | 3.77 |