Basic Information
ID: ALA4724670
Type: Binding
Description: Protac activity at CRBN/IRAK4 in human TMD8 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation by measuring reduction in IRAK4 protein level at 1 uM incubated for 24 hrs by Western blot analysis
Format: BAO_0000219
Organism: Homo sapiens
Cell type: TMD8
Target: Protein cereblon/IRAK4(ALA4523710)
Document: ALA4715903
Protac activity at CRBN/IRAK4 in human TMD8 cells harboring MYD88 L265P mutant assessed as induction of IRAK4 degradation by measuring reduction in IRAK4 protein level at 1 uM incubated for 24 hrs by Western blot analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4724670
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 804.83 | 5.01 | 5.01 |
| 846.91 | 6.18 | 6.18 |
| 820.83 | 4.24 | 4.24 |
| 832.88 | 5.79 | 5.79 |
| 878.91 | 4.60 | 4.60 |
| 776.77 | 4.23 | 4.23 |
| 818.85 | 5.40 | 5.40 |
| 790.80 | 4.62 | 4.62 |
| 864.88 | 4.26 | 4.26 |