Basic Information
ID: ALA4724827
Type: Binding
Description: Inhibition of BRD4 in human PBMC assessed as reduction in LPS-induced TNFalpha secretion preincubated for 1 hr followed by LPS-stimulation and measured after 20 hrs by magnetic beads technique based assay
Format: BAO_0000357
Organism: Homo sapiens
Target: Bromodomain-containing protein 4(ALA1163125)
Document: ALA4715913
Inhibition of BRD4 in human PBMC assessed as reduction in LPS-induced TNFalpha secretion preincubated for 1 hr followed by LPS-stimulation and measured after 20 hrs by magnetic beads technique based assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA4724827
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 423.90 | 3.66 | 3.66 |
| 375.38 | 3.46 | 3.46 |
| 352.44 | 3.15 | 3.15 |
| 355.46 | 3.54 | 3.54 |
| 369.42 | 3.19 | 3.19 |
| 357.39 | 3.32 | 3.32 |
| 352.44 | 3.15 | 3.15 |
| 373.84 | 3.83 | 3.83 |
| 357.39 | 3.32 | 3.32 |
| 387.46 | 2.22 | 2.22 |
| 339.40 | 3.18 | 3.18 |
| 380.49 | 4.20 | 4.20 |
| 380.49 | 4.20 | 4.20 |